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Publications

Independent publications

17. Ifedi Orizu and Yuri Bolshan
A General Brønsted Acid-Catalyzed Allylation of Benzhydryl Alcohols.
Tetrahedron Lett. 2016, 57, 5798-5800.

orizu allylation of alcohols

16. Kayla M. Fisher and Yuri Bolshan
Brønsted Acid-Catalyzed Direct Substitution of 2-Ethoxytetrahydrofuran with Trifluoroborate Salts.
Catalysts 2016, 6, 94-102 (invited contribution)

Fisher_catalysts

15. Kayla M. Fisher and Yuri Bolshan
Brønsted Acid-Catalyzed Reactions of Trifluoroborate Salts with Benzhydryl Alcohols.
J. Org. Chem. 2015, 80, 12676–12685.

Fisher JOC 2015

14. Matthew Baxter and Yuri Bolshan
A General Access to Propargylic Ethers through Brønsted Acid Catalyzed Alkynylation of Acetals and Ketals with Trifluoroborates.
Chem. Eur. J. 2015, 21, 13535-13538.

Baxter_ChemEurJ_2015

13. Cassandra Taylor and Yuri Bolshan
Metal-free methodology for the preparation of sterically hindered alkynoylphenols and its application to the synthesis of flavones and aurones.
Tetrahedron Lett. 2015, 56, 4392-4396.

C. Taylor_2015

12. Cassandra Taylor and Yuri Bolshan
Metal-Free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts.
J. Vis. Exp. 2015, 96, e52401.
Journal of Visualized Experiments (JoVE) is the first peer reviewed scientific video journal.
http://www.jove.com/video/52401/metal-free-synthesis-ynones-from-acyl-chlorides-potassium

11. Cassandra Taylor and Yuri Bolshan
Metal-Free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts.
Org. Lett. 2014, 16, 488-491.

taylor 2013

Postdoc, PhD and Undergrad

10. Bolshan, Y.; Getlik, M.; Kuznesova, E. Wasney, G.; Hajian, T.; Poda, G.; Nguyen, K.; Wu, H.; Dombrovski, L.; Dong, A.; Schapira, M.; Arrowsmith, C.; Brown, P.; Al-awar, R.; Vedadi, M.; Smil, D.
Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.
ACS Med. Chem. Lett. 2013, 4 (3), 353-357

9. Bullwinkle, T. J.; Zou, S. B.; Rajkovic, A.; Hersch, S. J.; Elgamal, S.; Robinson, N.; Smil, D.; Bolshan, Y.; Navarre, W. W.; Ibba, M.
(R)-beta-Lysine-modified Elongation Factor P Functions in Translation Elongation.
J. Biol. Chem. 2013, 288 (6), 4416–4423.

8. Yu, W.; Smil, D.; Li, F.; Tempel, W.; Fedorov, O.; Nguyen, K. T.; Bolshan, Y.; Al-Awar, R.; Knapp, S.; Arrowsmith, C. H.; Vedadi, M.; Brown, P. J.; Schapira, M.
Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.
Bioorg. Med. Chem. 2012, 21, 1787-1794.

7. Senisterra, G.; Wu, H.; Allali-Hassani, A.; Wasney, G. A.; Barsyte-Lovejoy, D.; Dombrovski, L.; Dong, A.; Nguyen, K. T.; Smil, D.; Bolshan, Y.; Hajian, T.; He, H.; Seitova, A.; Chau, I.; Li, F.; Poda, G.; Couture, J.-F.; Brown, P. J.; Al-awar, R.; Schapira, M.; R.; Arrowsmith, Vedadi, M.
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem. J. 2013, 449, 151–159.

6. Siarheyeva, A.; Senisterra, G.; Allali-Hassani, A.; Dong, A.; Dobrovetsky, E.; Wasney, G. A.; Chau, I.; Nguyen, K. T.; Marcellus, R.; Hajian, T.; Liu, F.; Smil, D.; Bolshan, Y.; Min, J.; Poda, G.; Bedford, M.; Brown, P. J.;  Jin, J.; Al-awar, R.; Arrowsmith, C. H.; Schapira, M.; Vedadi, M.
Discovery of an allosteric inhibitor of arginine methyltransferase PRMT3.
Structure 2012, 20, 1425-1435.

5. Bolshan, Y. and Batey, R. A.
Copper-Catalyzed Cross-Coupling of Amides and Potassium Alkenyltrifluoroborate Salts: A General Approach to the Synthesis of Enamides.
Tetrahedron 2010, 68, 5283-5294.

4. Bolshan, Y. and Batey, R. A.
Copper-catalyzed coupling of amides with potassium alkenyltrifluoroborate salts.
Angew. Chem. Int. Ed. 2008, 47, 2109-2112. (VIP” publication)

3. Bolshan, Y.; Tomaszevski, M. and Santhakumar, V.
Thiol on silica as a 'catch and release' support for isocyanates to afford ureas.
Tetrahedron Lett. 2007, 48, 4925-4927.

2. Bolshan, Y. and Batey, R. A.
A Room-Temperature Protocol for the Rhodium(I)-Catalyzed Addition of Arylboron Compounds to Sulfinimines.
Org. Lett. 2005, 7, 1481-1484.

1. Bolshan, Y.; Chen, C.; Chilenski, J. R.; Gosselin, F.; Mathre, J.; O'Shea, P. D.; Roy, A.; Tillyer, R. D.
Nucleophilic Displacement at Benzyhydril Centers: Asymmetric Synthesis of 1,1’-Diarylalkyls Derivatives.
Org. Lett. 2004, 6, 111-114. 

Crystal Structures

Dong, A.; Dombrovski, L.; Senisterra, G.; Wernimont, A.; Wasney, G. A.; Allali Hassani, A.; Nguyen, K. T.;  Smil, D.; Bolshan, Y.; Hajian, T.; Poda, G.; Chau, I.; Al-awar, R.; Bountra, C.; Weigelt, J.; Edwards, A. M.; Arrowsmith, C. H.; Brown, P.; Schapira, M.; Vedadi, M.; Wu, H.
Crystal structure of human WD repeat domain 5 with compound.
RCSB PDB
2011, PDB ID: 3UR4.

Dong, A.; Dombrovski, L.; Wasney, G.A.; Tempel, W.; Senisterra, G.; Bolshan, Y.; Smil, D.; Nguyen, K. T.; Hajian, T.; Poda, G.; Al-Awar, R.; Bountra, C.; Weigelt, J.; Edwards, A. M.; Brown, P.J.; Schapira, M.; Arrowsmith, C. H.; Vedadi, M.; Wu, H.
Crystal structure of human WD repeat domain 5 with compound.
RCSB PDB 2011, PDB ID: 3SMR.

Dobrovetsky, E.; Dong, A.; Walker, J. R.; Siarheyeva, A.; Senisterra, G.; Wasney, G. A.; Smil, D.; Bolshan, Y.; Allali-Hassani, A.; Hajian, T.; Poda, G.; Bountra, C.; Weigelt, J.; Edwards, A. M.; Al-Awar, R.; Brown, P. J.; Schapira, M.; Arrowsmith, C. H.; Vedadi, M.
Crystal structure of protein arginine methyltransferase 3.
RCSB PDB 2011, PDB ID: 3SMQ.

Mottaghi, K.; Tempel, W.; Hong, B.; Smil, D.; Bolshan, Y.; Wernimont, K.; Arrowsmith, C. H.; Edwards, A. M.; Bountra, C.; Weigelt, J.; Park, H.
Human Pantothenate kinase 3 in complex with a pantothenate analog.
RCSB PDB 2011, PDB ID: 3SMS.

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